ABSTRACT
Introduction: Two facts have been constantly reported in the literature over the lastdecades, namely: the increased number of reproductive-age women with cancer and theincreased age of primiparas. Both facts have encouraged studies on strategies to preserve women?s fertility. Objectives: To perform vaginal swab and morphological study to assess the functional viability of transplanted ovarian tissue. Methods: 30 female Wistar ablbinus mice with preserved hormonal function were randomly distributed in six groups: G1. Control ? laparotomy; G2. Bilateral oophorectomy. G3. Bilateral oophorectomy with intact ovarian implant in the femoral region; G4. Bilateral oophorectomy, with sliced ovarian implant in the femoral region; G5. Bilateral oophorectomy with intact ovarian implant in the great epiploon; G6. Bilateral oophorectomy with sliced ovarian implantat in the great epiploon. Vaginal swab and removal for morphological study of the transplanted ovaries were carried out on the 35th and 120th days after surgery. Groups G3 and G6 were submitted to new vaginal swab on the 150th day. Results: All G1 mice had hormonal function. All G2mice remained in diestrus. The patterns of four G3 mice were consistent with estrus on the 35th day, and one mouse ovulated on the 120th day. Only one G4 mouse remained in diestrus after transplantation. All G5 had functioning ovary. Four G6 mice manifested hormonal function on the 35th day and only three on the 120th day. All the 150th-day swabs were classified as diestrus.Conclusions: Autologous ovarian transplant is technically feasible in female mice as much as vaginal swab for hormonal function assessment.
ABSTRACT
Introdução: O carcinoma mucoepidermóide é a neoplasia maligna mais comum das glândulas salivares, sendo o principal sítio de acometimento a parótida. Ocorre também em glândulas salivares menores desde a cavidade nasal até os pulmões. A localização nasal do carcinoma mucoepidermóide é extremamente rara. A literatura é pobre em casos semelhantes. Objetivo: Relatar um caso de carcinoma mucoepidermóide de septo nasal à direita, abordando aspectos gerais quanto a patogênese, diagnóstico, terapêutica e seguimento pós-operatório. Relato do Caso: Apresentamos um caso de uma paciente de 32 anos com história de obstrução nasal, epistaxe e tumoração em fossa nasal direita. A biópsia revelou tratar-se de carcinoma mucoepidermóide. Realizamos ressecção tumoral por via nasal endoscópica, associada à radioterapia complementar. O anátomo-patológico classificou-o como de alto grau de malignidade. Obteve remissão dos sintomas e sem recidiva em seguimento. Conclusão: As massas tumorais nasais devem ser estudadas com exames de imagem e histopatologia. Podemos nos surpreender com tumores malignos nasais raros.
Introduction: Mucoepidermoid carcinoma is the most common malignant neoplasm of the salivary glands, and the parotid is the main site of attack. It also occurs in the minor salivary glands from the nasal cavity to the lungs. Nasal location of the mucoepidermoid carcinoma is extremely rare. There is little literature on similar cases. Objective: To report a case of mucoepidermoid carcinoma of the right nasal septum, and cover general aspects of the pathogenesis, diagnosis, therapy, and post-operative follow-up. Case Report: We present a case of a 32-year-old patient with a history of nasal obstruction, epistaxis and tumoration in the right nasal cavity. The biopsy revealed it was a mucoepidermoid carcinoma. The tumor was surgically removed using endoscopes with associated complementary radiotherapy. The anatomopathological analysis classified it with a high degree of malignancy. We obtained remission of the symptoms and without subsequent recurrence. Conclusion: Tumor nasal masses should be studied with imaging and histopathology examinations. We may discover rare malignant nasal tumors.